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Lab cells made of lab to relieve baldness can be on the way

The greatest breakthrough came in the early 2000’s, when Japanese researchers used a simple method of transplanting any type of muscle into a single cell, similar to that in an embryo’s stomach. The ideas were crazy. Scientists have discovered that they can produce infinite amounts of material in almost every kind of cell, such as nerve cells or the heart muscle.

In systems, however, the process of making certain types of cells may be impossible, so there is a problem with the replacement of lab-produced cells in the body. So far, there have been only a few demonstrations of rehab as a way to treat patients. Researchers in Japan are trying to place them and retinal cells being blind people. Then, last November, the US company, Vertex Pharmaceuticals, said she would probably cure a man of type 1 diabetes After insertion into the created beta cells, which respond to insulin.

The idea followed by the founders is to collect normal cells from the patients, say the skin, and then transform them into hair-producing cells. In addition to dNovo, a company called Stemson (named stem cell portmanteau by Samson) has secured $ 22.5 million plus from pharmaceutical company AbbVie. Co-founder and CEO Geoff Hamilton says his company is genetically modifying cells in the skin of mice and pigs to test the technology.

Both Hamilton and Lujan think there is a big market. About half of men have the same baldness as men, the other starting in their 20’s.

These companies are bringing advanced biology to companies that are known to be fake. There are many myths about hair treatment and cell viability. “You need to be aware of fraud,” said Paul Knoepfler, a cell scientist at UC Davis, wrote in November.

Near the organoid skin covered with hair follicles.

JIYOON LEE NDI KARL KOEHLER, HARVARD MEDICAL SCHOOL

Fraudulent business

So does stem cell technology cure baldness or false hope? Hamilton, founder of Stemson, was invited to comment this year International Hair Loss Convention, and he says he tried to emphasize that the company still has a lot of research head. “We have seen many [people] come and say he has an answer. This has happened to a lot of hair, so I have to deal with it, “says Hamilton.

Currently, there are legal hair removal medications, such as Propecia and Rogaine, but they are less effective. Another option is for the surgeon to cut out the hair follicles while the hair is still in place and to apply the bullets to the foot. Lujan states that in the future, hair follicles grown in the lab may be implanted in a person’s head with the same surgery.

“I think people have gone to great lengths to restore their hair. But at first it will be a very popular and expensive procedure,” says Karl Koehler, a professor at Harvard University.

Hair follicles are amazingly complex organisms that emerge through a molecular crosstalk between several cell types. And Koehler argues that images of mice that grow on human hair are not new. Koehler observes: “Every time you look at it, you see that there is a deception and a hindrance to translation.”

Koehler Lab makes hair extensions in a very different way – by enhancing organoids. Organoids are small pieces of cells that form spontaneously in a petrol dish. Koehler states that he had originally studied the healing properties of the deaf and had sought to enlarge the inner ear. But her organoids were able to become skinny instead, full of hair follicles.

Koehler accepted the accident and is now developing spherical skin organoids that can grow for about 150 days and become larger – about two millimeters across. The tube hair follicles look good and, he says, are similar to the earthy hairs that cover the fetus.

One amazing thing is that organoids grow backwards, with hair pointing inwards. “You can see the decorative architecture even why they grow inside is a big question,” says Koehler.

Harvard Lab uses recycled cells made from a 30-year-old Japanese man. But it is looking at cells from other providers to see if organoids can cause hair to have different colors and shapes. Koehler states: “There is a great need. “The jewelry industry is interested. Their eyes light up when they see organoids. ”


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